Headaches

Does Wine Cause Headaches?

We’ve all been there: you enjoy a glass of wine in the evening, only to wake up with a throbbing headache the next day. Was it the wine? If so, what in the wine caused it? Before you swear off wine forever, it’s important to separate myth from fact.

At Liquor and Smoke House, your trusted liquor store in Lebanon, TN, we often hear questions like this from customers. So let’s break it down.

The Sulfite Myth

One of the most common wine-related myths is that sulfites cause headaches. While wine bottles are required to state that they contain sulfites, there’s no strong evidence linking them to headaches in most people.

In fact:

  • White wines usually have more sulfites than reds.
  • Common foods like dried fruits, lunch meats, and processed snacks have much higher sulfite levels than wine.
  • Only about 1% of the population is genuinely sensitive to sulfites, usually in the form of respiratory issues—not headaches.

So if you’re blaming sulfites for your post-wine discomfort, it might be time to look elsewhere.

Tannins and Serotonin

Tannins are naturally occurring compounds found in grape skins, seeds, and stems. They’re more prevalent in red wines, giving them that dry, structured finish. Some studies suggest tannins stimulate serotonin production in the brain. While too much serotonin could trigger headaches in some people, it’s worth noting that tannins are also found in:

  • Tea
  • Dark chocolate
  • Soy products

If these don’t give you headaches, it’s unlikely that tannins in wine are the cause.

Histamines: Rare but Possible

Histamines are another compound found in wine, especially reds. Some people have lower levels of the enzyme (DAO) needed to break histamines down, which could lead to:

  • Flushing
  • Headaches
  • Nausea

However, the Journal of Allergy and Clinical Immunology reports that histamine-related wine reactions are extremely rare. If you suspect histamines are the issue, try taking an over-the-counter antihistamine like Claritin an hour before drinking. If your symptoms ease, histamines might be your trigger.

Prostaglandins and Pain

Prostaglandins are naturally occurring substances in the body that regulate muscle contractions and inflammation. In rare cases, drinking wine may cause your body to release excess prostaglandins, resulting in headaches.

If this is the case, Ibuprofen, acetaminophen, or aspirin (taken beforehand) may help inhibit these effects.

Other Possible Triggers

Even if none of the above are to blame, other factors could be:

  • Dehydration (especially with alcohol, which is a diuretic)
  • Low blood sugar if you drank wine without eating
  • Congeners, natural byproducts of fermentation more prevalent in red wines
  • Alcohol content, particularly in high-proof wines

Don’t Give Up Wine-Experiment Instead

If you suspect wine gives you headaches, don’t give up your favorite vintage just yet. Try experimenting:

  • Switch from red to white or vice versa
  • Drink with food, not on an empty stomach
  • Try lower-alcohol wines
  • Hydrate before, during, and after drinking
  • Keep track of which wines cause symptoms and which don’t

And of course, visit Liquor and Smoke House for personalized recommendations. Our team is happy to help you explore new wines and avoid the ones that might be causing discomfort.

Visit Lebanon’s Trusted Wine Experts

At Liquor and Smoke House, we offer an expertly curated selection of red, white, and sparkling wines that cater to all preferences and sensitivities. Whether you’re looking for organic wines, low-sulfite options, or something gentle on the palate, we’ve got you covered.

Why Choose Us?

Locally trusted liquor store in Lebanon, TN

Knowledgeable staff with wine pairing advice

Wide range of domestic and international wines

Convenient location and online browsing at liquorandsmokehouse.com

Wine doesn’t automatically cause headaches—but for some, certain compounds might trigger discomfort. With a little experimentation and expert guidance, you can often find a wine that agrees with your body and your taste buds.

If you’re ready to explore headache-free options, Liquor and Smoke House is here to help you sip smarter and enjoy more.

Stop by today or visit us online to find your next favorite wine minus the headache.